Ampicillin sodium I.P.
Pharmacology and Mechanism of Action
Beta-lactam antibiotic. Ampicillin inhibits bacterial cell wall synthesis. Ampicillin has a narrow spectrum of activity that is similar to that of amoxicillin.
Pharmacokinetics of ampicillin indicated that the half-life is approximately 1- 1.5 hours in most animals. When the trihydrate formulation is injected IM, it produces a lower peak concentration but a longer half-life of 6.7 hours in cattle.
Indications and Clinical Uses
Ampicillin is indicated in patients with infections caused by susceptible bacteria, such as skin and soft tissue infections, UTIs, and pneumonia.
Dogs
• 10-50 mg/kg q12-24h IM or SQ.
Cats
• 10-20 mg/kg q12-24h IM or SQ.
Large Animal Dosage
Cattle and Calves
Ampicillin Trihydrate
• 4.4 to 11 mg/kg q24h IM.
body weight once daily.
Small Animals 11 to 22 mg per kg body weight once daily, through IM or IV route for 3 to 5 days or as recommended by the Veterinarian Pack: 1 gm, 2 gm & 2.5 gm vial
