Pharmacology and Mechanism of Action
Ketoprofen, like other NSAIDs, produces analgesic and anti-inflammatory effects by inhibiting the synthesis of prostaglandins. The enzyme inhibited by NSAID is the cyclo-oxygenase enzyme (COX).
Indications and Clinical Uses
Ketoprofen is an NSAID and is used for the treatment of moderate pain and inflammation. It has a half-life in most animals of less than 2 hours, but it has a duration of action for up to 24 hours. It has been given by injection for acute treatment and by tablet for long-term use. In dogs and cats, it has been shown effective for treating pyrexia. Ketoprofen also has been used in cattle, goats, sheep, and pigs. In cattle, it has been effective for fever, pain, and inflammation associated with mastitis.
Adverse Reactions and Side Effects
All NSAIDs share the similar adverse effect of GI toxicity. Bleeding problems can occur if ketoprofen is administered before or after surgery.
Do not administer with other NSAIDs or with corticosteroids. Corticosteroids have been shown to exacerbate the GI adverse effects.
Instructions for Use
Small Animal Dosage
Dogs and Cats
• 1 mg/kg q24h PO for up to 5 days. Initial dose can be given via injection at up
to 2 mg/kg SQ, IM, or IV.
Large Animal Dosage
• 3 mg/kg/day, PO, IV or IM.
Cattle and Small Ruminants
• 3 mg/kg/day IV or IM for up to 3 days.
Cattle- 3 mg/kg B.wt.
Horse- 2.2 mg/kg B.wt.
30 ml & 100 ml vial