,

PAINTAGON bolus

Each uncoated bolus contains:

Meloxicam I.P lOOmg; Paracetamol I.P 1500mg; Excipient q.s

Immune system creates inflammation to protect the body from infection, injury, or disease. Without inflammation body is unable to heal.
NSAID (Non steroid Anti-inflammatory Drug) is applied to drugs that inhibit one or more steps in the metabolism of arachidonic acid (AA) which is produce from the damaged cells.
NSAIDs act primarily to reduce the biosynthesis of prostaglandins by inhibiting cyclooxygenase (COX).
COX-1, expressed in virtually all tissues of the body (e.g., gut and kidney), catalyzes the formation of constitutive prostaglandins, which mediate a variety of normal physiologic effects, including hemostasis,
Gl mucosal protection, and protection of the kidney from hypotensive insult.
In contrast, COX-2 is activated in damaged and inflamed tissues and catalyzes the formation of inducible prostaglandin, including PGE2, associated with intensifying the inflammatory response.

COX-2 is also involved in thermoregulation and the pain response to injury.

Therefore, COX-2 inhibition by NSAIDs is thought to be responsible for the antipyretic, analgesic, and anti-inflammatory actions of NSAIDs.

However, concurrent inhibition of COX-1 may result in many of the unwanted effects of NSAIDs. including gastric ulceration and renal toxicity. Because NSAIDs vary in their ability to inhibit each COX isoform, a drug that inhibits COX-2 at a lower concentration than that necessary to inhibit COX-1 would be considered safer.

This concept has propelled the development of the “COX-2 selective” NSAIDs.

Indications:

Pneumonia; Broncho-pneumonia; Pleuritis;
Laminitis;Myositis; Sprain; Arthritis (rheumatoid origin also); Mastitis; Prolapse of uterus; Otitis; Premature labor, Pyrexia and follow up with Moxicam P Injection

Dosage in large animals: lbolus /100kg Body weight or as directed by Veterinary Practitioners.

Presentation;  Blister of 4 boli and box of lOBlisters

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