Composition :
Each vial contains: Ampicillin Sodium IP 2 gm + Dicloxacillin 2 gm
Pharmacology and Mechanism of Action
Beta-lactam antibiotic. Ampicillin inhibits bacterial cell wall synthesis. Ampicillin has a narrow spectrum of activity that is similar to that of amoxicillin.
Pharmacokinetics of ampicillin indicated that the half-life is approximately 1- 1.5 hours in most animals. When the trihydrate formulation is injected IM, it produces a lower peak concentration but a longer half-life of 6.7 hours in cattle.
Indications and Clinical Uses
Ampicillin is indicated in patients with infections caused by susceptible bacteria, such as skin and soft tissue infections, UTIs, and pneumonia.
Dogs
• 10-50 mg/kg q12-24h IM or SQ.
Cats
• 10-20 mg/kg q12-24h IM or SQ.
Large Animal Dosage
Cattle and Calves
Ampicillin Trihydrate
• 4.4 to 11 mg/kg q24h IM.
Cloxacillin
Cloxacillin is similar in spectrum and activity as amoxicillin. Cloxacillin in combination with Ampicillin in will provide better Synergistic Bactericidal effect against Gram+ve, Gram-veas well as Beta Lactamase & Penicillinase. Cloxacillin has the greatest antimicrobial activity in its group against Penicillinase producting resistant strain of Staphylococcus ahreus the notorious causative organism of mastitis.
Mastitis H.S.
Pneumonia Bronchitis B.Q.
Calf Scours
Bacterial Gastroenteritis Metritis Pyometra Leptospirosis Listeriosis Cystitis
Otitis Externa and Interna Urogenital tract Infection Retained Placenta E.Coli Infection Respiratory tract Infection Bronchitis and Surgical Wounds.
Dosage:
Cattle, Buffaloes: 6-10 mg/kg b.wt. for 3-5 days by IM or IV route
4 gm vial with 20 ml w.f.i
